Medicines of the central action, such as Neurontin are used for the treatment of neuralgia and convulsive attacks. These drugs should render selective effect on the mechanisms of pain development and convulsive attacks, without affecting other neural mechanisms. Neurontin meets all these requirements.
The active substance of Neurontin is Gabapentin. This drug is similar to gamma-aminobutyric acid (GABA) in its structure, but it does not have affinity with GABA receptors.
Analgesic and anticonvulsant effect of Gabapentin is associated with blocking of the flow of calcium ions, responsible for the neuropathic pain appearance. In addition, Gabapentin indirectly increases the synthesis of GABA.
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